Extramedullary Hematopoiesis Manifesting as a Symptomatic Pleural Effusion

Rachelina P. Bartlett, Philip R. Greipp, Ayalew Tefferi, Roger E. Cupps, Brian P. Mullan, Victor F. Trastek

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


The occurrence of extramedullary hematopoiesis in the pleura is rare and is usually asymptomatic. It is generally diagnosed on postmortem examination. Herein we describe a 61-year-old woman with agnogenic myeloid metaplasia who sought medical assessment because of progressive dyspnea. Thoracentesis yielded sanguineous fluid with 10% myeloblasts. A 99mTc bone marrow scan demonstrated increased tracer activity throughout both lungs, an outcome consistent with extramedullary hematopoiesis. Fine- needle aspiration and video-assisted thoracoscopy were considered but deferred because of the potential risk of profuse bleeding. Treatment with low-dose external beam irradiation to the left posterior pleura was successful. To date, no hemothorax has recurred.

Original languageEnglish (US)
Pages (from-to)1161-1164
Number of pages4
JournalMayo Clinic proceedings
Issue number12
StatePublished - 1995


  • AMM
  • CT
  • EMH
  • agnogenic myeloid metaplasia
  • computed tomography
  • extramedullary hematopoiesis

ASJC Scopus subject areas

  • Medicine(all)


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