Exploration of the gastrinoma triangle

Michael G. Sarr, Jeffrey A. Norton

Research output: Chapter in Book/Report/Conference proceedingChapter


Gastrin-secreting neoplasms were first described by Zollinger and Ellison in 1955. These unusual neoplasms can be either benign or malignant. The diagnosis of the Zollinger-Ellison syndrome depends on an increased fasting serum gastrin concentration (>100pg/ml), increased basal acid output (>10mEq/l), and an abnormal secretin test (increase of >200pg/ml in serum gastrin concentration after 2U/kg of intravenous secretin). While originally believed to be primarily neoplasms of the pancreas, today we know that most curable gastrinomas arise in the wall of the proximal duodenum. Gastrinomas can occur as sporadic (non-familial) neoplasms or as one of the manifestations of multiple endocrine neoplasia-1 syndrome (MEN-1); MEN-1 includes neoplasms of the pituitary and parathyroids, neuroendocrine neoplasms of the duodenum and pancreas, and carcinoid neoplasms of the foregut and midgut.

Original languageEnglish (US)
Title of host publicationAtlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery
PublisherSpringer Berlin Heidelberg
Number of pages7
ISBN (Print)9783540200048
StatePublished - 2007

ASJC Scopus subject areas

  • General Medicine


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