Exosomes: the latest in regenerative aesthetics

Krishna S. Vyas; Joely Kaufman; Girish S. Munavalli; Kiran Robertson; Atta Behfar; Saranya P. Wyles

doi:10.2217/rme-2022-0134

Exosomes: the latest in regenerative aesthetics

Krishna S. Vyas
, Joely Kaufman
, Girish S. Munavalli
, Kiran Robertson
, Atta Behfar
, Saranya P. Wyles

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Regenerative aesthetics is a burgeoning field for skin rejuvenation and skin health restoration. Exosomes, or extracellular vesicles, represent a new and minimally invasive addition to the regenerative aesthetic toolbox. These nano-sized vesicles contain bioactive cargo with crucial roles in intercellular communication. Exosome technology, while still in its infancy, is now leveraged in regenerative aesthetic medicine due to its multifaceted role in targeting root causes of skin aging and improving overall tissue homeostasis. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility. This review aims at highlighting the current and emerging landscape of exosomes in aesthetic medicine including skin rejuvenation and hair restoration.

Original language	English (US)
Pages (from-to)	181-194
Number of pages	14
Journal	Regenerative Medicine
Volume	18
Issue number	2
DOIs	https://doi.org/10.2217/rme-2022-0134
State	Published - Jan 4 2023

Keywords

exosomes
extracellular vesicles
hair restoration
skin rejuvenation

ASJC Scopus subject areas

Biomedical Engineering
Embryology

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10.2217/rme-2022-0134

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title = "Exosomes: the latest in regenerative aesthetics",

abstract = "Regenerative aesthetics is a burgeoning field for skin rejuvenation and skin health restoration. Exosomes, or extracellular vesicles, represent a new and minimally invasive addition to the regenerative aesthetic toolbox. These nano-sized vesicles contain bioactive cargo with crucial roles in intercellular communication. Exosome technology, while still in its infancy, is now leveraged in regenerative aesthetic medicine due to its multifaceted role in targeting root causes of skin aging and improving overall tissue homeostasis. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility. This review aims at highlighting the current and emerging landscape of exosomes in aesthetic medicine including skin rejuvenation and hair restoration.",

keywords = "exosomes, extracellular vesicles, hair restoration, skin rejuvenation",

author = "Vyas, \{Krishna S.\} and Joely Kaufman and Munavalli, \{Girish S.\} and Kiran Robertson and Atta Behfar and Wyles, \{Saranya P.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Future Medicine Ltd. Plain language summary What is this article about? The purpose of this paper is to review available studies that look at the effects of exosomes in aesthetic medicine and cosmetic surgery. A thorough literature search of all available studies was performed. What were the results? Topical exosomes, although variable in source and method of isolation, are generally considered safe in humans on intact skin. The current published research literature does not yet provide a clear consensus on long-term use for skin rejuvenation or hair restoration, nor does it delineate which patients would benefit most from this technology. There are no currently US FDA-approved exosome products on the market for medical indications. What do the results of this literature review mean? More clinical studies with proper regulatory oversight are needed. </sec. ",

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doi = "10.2217/rme-2022-0134",

language = "English (US)",

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journal = "Regenerative Medicine",

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T2 - the latest in regenerative aesthetics

AU - Vyas, Krishna S.

AU - Kaufman, Joely

AU - Munavalli, Girish S.

AU - Robertson, Kiran

AU - Behfar, Atta

AU - Wyles, Saranya P.

N1 - Publisher Copyright: © 2023 Future Medicine Ltd. Plain language summary What is this article about? The purpose of this paper is to review available studies that look at the effects of exosomes in aesthetic medicine and cosmetic surgery. A thorough literature search of all available studies was performed. What were the results? Topical exosomes, although variable in source and method of isolation, are generally considered safe in humans on intact skin. The current published research literature does not yet provide a clear consensus on long-term use for skin rejuvenation or hair restoration, nor does it delineate which patients would benefit most from this technology. There are no currently US FDA-approved exosome products on the market for medical indications. What do the results of this literature review mean? More clinical studies with proper regulatory oversight are needed. </sec.

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AB - Regenerative aesthetics is a burgeoning field for skin rejuvenation and skin health restoration. Exosomes, or extracellular vesicles, represent a new and minimally invasive addition to the regenerative aesthetic toolbox. These nano-sized vesicles contain bioactive cargo with crucial roles in intercellular communication. Exosome technology, while still in its infancy, is now leveraged in regenerative aesthetic medicine due to its multifaceted role in targeting root causes of skin aging and improving overall tissue homeostasis. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility. This review aims at highlighting the current and emerging landscape of exosomes in aesthetic medicine including skin rejuvenation and hair restoration.

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KW - hair restoration

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Exosomes: the latest in regenerative aesthetics

Abstract

Keywords

ASJC Scopus subject areas

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