TY - JOUR
T1 - Excessive Daytime Sleepiness in Major Dementia Syndromes
AU - Boeve, Angelica
AU - Ferman, Tanis J.
AU - Aakre, Jeremiah
AU - St. Louis, Erik
AU - Silber, Michael
AU - Machulda, Mary
AU - Fields, Julie
AU - Graff-Radford, Neill
AU - Mielke, Michelle
AU - Geda, Yonas
AU - Jones, David
AU - Graff-Radford, Jonathon
AU - Knopman, David
AU - Petersen, Ronald
AU - Boeve, Brad
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Neill Graff-Radford, MD, receives research support from NIH, has received publishing royalties from UpToDate, Inc, and receives research support from Biogen, Lilly, Axovant, and Novartis. He has consulted for Cytox. Michelle Mielke, PhD, served as a consultant to Eli Lilly and Lysosomal Therapeutics, Inc. She receives research support from the NIH and unrestricted research grants from Biogen, Lundbeck, and Roche. David Knopman, MD, serves on a Data Safety Monitoring Board for Lundbeck Pharmaceuticals and for the DIAN study; is an investigator in clinical trials sponsored by TauRX Pharmaceuticals, Lilly Pharmaceuticals, Biogen and the Alzheimer’s Disease Cooperative Study; and receives research support from the NIH. Ronald Petersen, MD, PhD, serves on data monitoring committees for Pfizer, Inc, Janssen Alzheimer Immunotherapy; is a consultant for Biogen, Roche, Inc, Merck, Inc, and Genentech, Inc; receives publishing royalties from Mild Cognitive Impairment (Oxford University Press, 2003); and receives research support from the NIH. Brad Boeve, MD, is an investigator for clinical trials sponsored by Axovant and Biogen; receives royalties from the publication of a book entitled Behavioral Neurology of Dementia (Cambridge Medicine, 2009, 2017); serves on the Scientific Advisory Board of the Tau Consortium; and receives research support from the NIH, Mangurian Foundation, and the Little Family Foundation. This study was supported by P50 AG016574, R01 AG015866, Mayo Clinic Dorothy and Harry T. Mangurian Jr. Lewy Body Dementia Program, and Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program.
Publisher Copyright:
© The Author(s) 2019.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.
AB - There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.
KW - Alzheimer’s disease
KW - dementia with Lewy bodies
KW - excessive daytime sleepiness
KW - frontotemporal dementia
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U2 - 10.1177/1533317519828046
DO - 10.1177/1533317519828046
M3 - Article
C2 - 30740984
AN - SCOPUS:85061561638
SN - 1533-3175
VL - 34
SP - 261
EP - 264
JO - American Journal of Alzheimer's Disease and Other Dementias
JF - American Journal of Alzheimer's Disease and Other Dementias
IS - 4
ER -