Ex-situ machine perfusion in clinical liver transplantation: Current practices and future directions

Michelle C. Nguyen; Xingjie Li; Natalia Linares; Caroline Jadlowiec; Adyr Moss; Kunam S. Reddy; Amit K. Mathur

doi:10.1097/LVT.0000000000000428

Ex-situ machine perfusion in clinical liver transplantation: Current practices and future directions

Michelle C. Nguyen, Xingjie Li, Natalia Linares, Caroline Jadlowiec, Adyr Moss, Kunam S. Reddy, Amit K. Mathur

Research output: Contribution to journal › Review article › peer-review

Abstract

Ex-situ machine perfusion of the liver has surmounted traditional limitations associated with static cold storage in the context of organ preservation. This innovative technology has changed the landscape of liver transplantation by mitigating ischemia perfusion injury, offering a platform for continuous assessment of organ quality, and providing an avenue for optimizing the use of traditionally marginal allografts. This review summarizes the contemporary clinical applications of machine perfusion devices and discusses potential future strategies for real-time viability assessment, therapeutic interventions, and modulation of organ function after recovery.

Original language	English (US)
Pages (from-to)	531-544
Number of pages	14
Journal	Liver Transplantation
Volume	31
Issue number	4
DOIs	https://doi.org/10.1097/LVT.0000000000000428
State	Published - Apr 1 2025

Keywords

Liver Transplantation
Machine Perfusion

ASJC Scopus subject areas

Surgery
Hepatology
Transplantation

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10.1097/LVT.0000000000000428

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title = "Ex-situ machine perfusion in clinical liver transplantation: Current practices and future directions",

abstract = "Ex-situ machine perfusion of the liver has surmounted traditional limitations associated with static cold storage in the context of organ preservation. This innovative technology has changed the landscape of liver transplantation by mitigating ischemia perfusion injury, offering a platform for continuous assessment of organ quality, and providing an avenue for optimizing the use of traditionally marginal allografts. This review summarizes the contemporary clinical applications of machine perfusion devices and discusses potential future strategies for real-time viability assessment, therapeutic interventions, and modulation of organ function after recovery.",

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T2 - Current practices and future directions

AU - Nguyen, Michelle C.

AU - Li, Xingjie

AU - Linares, Natalia

AU - Jadlowiec, Caroline

AU - Moss, Adyr

AU - Reddy, Kunam S.

AU - Mathur, Amit K.

PY - 2025/4/1

Y1 - 2025/4/1

N2 - Ex-situ machine perfusion of the liver has surmounted traditional limitations associated with static cold storage in the context of organ preservation. This innovative technology has changed the landscape of liver transplantation by mitigating ischemia perfusion injury, offering a platform for continuous assessment of organ quality, and providing an avenue for optimizing the use of traditionally marginal allografts. This review summarizes the contemporary clinical applications of machine perfusion devices and discusses potential future strategies for real-time viability assessment, therapeutic interventions, and modulation of organ function after recovery.

AB - Ex-situ machine perfusion of the liver has surmounted traditional limitations associated with static cold storage in the context of organ preservation. This innovative technology has changed the landscape of liver transplantation by mitigating ischemia perfusion injury, offering a platform for continuous assessment of organ quality, and providing an avenue for optimizing the use of traditionally marginal allografts. This review summarizes the contemporary clinical applications of machine perfusion devices and discusses potential future strategies for real-time viability assessment, therapeutic interventions, and modulation of organ function after recovery.

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KW - Machine Perfusion

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Ex-situ machine perfusion in clinical liver transplantation: Current practices and future directions

Abstract

Keywords

ASJC Scopus subject areas

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