Evolution of computed tomographic abnormalities in leptomeningeal metastases

Kurt A. Jaeckle, George Krol, Jerome B. Posner

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We obtained serial cranial computed tomography (CT) scans from 25 patients with documented leptomeningeal metastases in orders to correlate the course of clinical symptoms and cerebrospinal fluid abnormalities with the evolution of CT abnormalities. In almost one‐third of patients, relatively specific CT finding such as enhancement of the meninges, obliteration of cisterns or sulci, and hydrocephalus with transependymal edema preceded clinical symptoms. By the time patients became symptomatic, 10 of 25 (40%) had specific abnormalities, and 4 more became specifically abnormally with time. The first scan after cerebrospinal fluid tumor cells were discovered showed specific abnormalities in only 6 patient, but 7 more became specifically abnormal with time. Ventriculomegaly occurred in 18 of 25 patients (72%) and was associated with sulcal and/or cisternal obliteration in one‐half of the patients. In 4 patients sulcal and cisternal obliteration developed prior to ventricular enlargement. Multiple small, enhancing cortical nodules were detected prior to symptom onset and discovery of leptomeningeal tumor in 5 patients.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalAnnals of neurology
Issue number1
StatePublished - Jan 1985

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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