Evaluation of Elevated Liver Enzymes

Tae Hoon Lee, W. Ray Kim, John J. Poterucha

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Liver enzymes, including aminotransferases and alkaline phosphatase, are some of the most commonly ordered blood tests in a physician's practice. These enzymes have been valuable in screening for liver disease, as well as in diagnosing and monitoring patients with acute and chronic hepatobiliary disorders. Patients with predominantly aminotransferase elevations are thought to have acute or chronic hepatitis from a variety of causes. In patients with predominantly alkaline phosphatase elevations, imaging evaluation is undertaken upfront to exclude large bile duct disorders and infiltrative/mass lesions. A liver biopsy may be reserved for patients for whom these less invasive investigations are unfruitful.

Original languageEnglish (US)
Pages (from-to)183-198
Number of pages16
JournalClinics in liver disease
Issue number2
StatePublished - May 2012


  • Alkaline phosphatase
  • Aminotransferase
  • Diagnostic algorithm
  • Gamma glutamyl transferase
  • Liver enzymes

ASJC Scopus subject areas

  • Hepatology


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