@article{301bf02a707f42939dea96cb3f00c3f2,
title = "Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples",
abstract = "Background: Associations between schizophrenia (SCZ) and polymorphisms at the regulator of G-protein signaling 4 (RGS4) gene have been reported (single nucleotide polymorphisms [SNPs] 1, 4, 7, and 18). Yet, similar to other SCZ candidate genes, studies have been inconsistent with respect to the associated alleles. Methods: In an effort to resolve the role for RGS4 in SCZ susceptibility, we undertook a genotype-based meta-analysis using both published and unpublished family-based and case-control samples (total n = 13,807). Results: The family-based dataset consisted of 10 samples (2160 families). Significant associations with individual SNPs/haplotypes were not observed. In contrast, global analysis revealed significant transmission distortion (p = .0009). Specifically, analyses suggested overtransmission of two common haplotypes that account for the vast majority of all haplotypes. Separate analyses of 3486 cases and 3755 control samples (eight samples) detected a significant association with SNP 4 (p = .01). Individual haplotype analyses were not significant, but evaluation of test statistics from individual samples suggested significant associations. Conclusions: Our collaborative meta-analysis represents one of the largest SCZ association studies to date. No individual risk factor arose from our analyses, but interpretation of these results is not straightforward. Our analyses suggest risk due to at least two common haplotypes in the presence of heterogeneity. Similar analysis for other putative susceptibility genes is warranted.",
keywords = "RGS4, association, linkage, meta-analysis, polymorphism, schizophrenia",
author = "Talkowski, {Michael E.} and Howard Seltman and Bassett, {Anne S.} and Brzustowicz, {Linda M.} and Xiangning Chen and Chowdari, {Kodavali V.} and Collier, {David A.} and Quirino Cordeiro and Corvin, {Aiden P.} and Deshpande, {Smita N.} and Egan, {Michael F.} and Michael Gill and Kendler, {Kenneth S.} and George Kirov and Heston, {Leonard L.} and Pat Levitt and Lewis, {David A.} and Tao Li and Karoly Mirnics and Morris, {Derek W.} and Nadine Norton and O'Donovan, {Michael C.} and Owen, {Michael J.} and Christian Richard and Prachi Semwal and Sobell, {Janet L.} and {St Clair}, David and Straub, {Richard E.} and Thelma, {B. K.} and Homero Vallada and Weinberger, {Daniel R.} and Williams, {Nigel M.} and Joel Wood and Feng Zhang and Bernie Devlin and Nimgaonkar, {Vishwajit L.}",
note = "Funding Information: This work was supported by grants from the National Institute of Mental Health (NIMH) (MH56242 and MH53459 to VLN), (K02 MH070786 to KM), (MH62440 to LMB), the Indo-US Project Agreement (#N-443-645 to VLN and BKT), an NIMH Conte Center for the Neuroscience of Mental Disorders (MH051456 to DAL), The Intramural Research Program of NIMH (DRW, RES, MFE), United Kingdom MRC (MJO, GK, MCO, and NMW), Science Foundation of Ireland (MG, DWM, APC), The National Science Foundation of China (TL), Welcome Trust (TL and DAC), NARSAD (TL), The Schizophrenia Research Fund (TL and DAC), GSK (FZ and DS), The Canadian Institutes of Health Research (ASB), The Bill Jefferies Schizophrenia Endowment Fund (ASB), Canada Research Chair in Schizophrenia Genetics (ASB), NARSAD (ASB), and Janssen Research Foundation funded family recruitment in Bulgaria. ",
year = "2006",
month = jul,
day = "15",
doi = "10.1016/j.biopsych.2006.02.015",
language = "English (US)",
volume = "60",
pages = "152--162",
journal = "Biological psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "2",
}