Etoposide-resistance in the multidrug-resistant LZ-8 cells

V. Liengswangwong, M. G. Haddock, M. A. Sognier, J. A. Belli, J. A. Bonner

Research output: Contribution to journalArticlepeer-review


The multidrug-resistant LZ-8 cells were found to exhibit marked resistance to etoposide compared to wild-type, parental V79 cells. The multidrug resistant phenotype did not significantly contribute to this etoposide-resistance. Following exposure of LZ-8 cells and V79 cells to equivalent concentrations of etoposide, there was a dramatic reduction in the number of etoposide-induced stabilized DNA-topoisomerase II complexes in the LZ-8 cells compared to V79 cells, however, this reduction was not found when nuclei isolated from LZ-8 and V79 cells were exposed to equivalent concentrations of etoposide. These results suggest that cytoplasmic factors are involved in the etoposide-resistance of LZ-8 cells.

Original languageEnglish (US)
Pages (from-to)773-780
Number of pages8
JournalBiochemistry and Molecular Biology International
Issue number4
StatePublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics


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