@article{7b6ac50551c940339f3ab8008fdf9d73,
title = "Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report",
abstract = "Background There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients{\textquoteright} values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.",
keywords = "cough, evidence-based medicine, pediatrics",
author = "{CHEST Expert Cough Panel} and Chang, {Anne B.} and Oppenheimer, {John J.} and Miles Weinberger and Grant, {Cameron C.} and Rubin, {Bruce K.} and Irwin, {Richard S.} and Altman, {Kenneth W.} and Elie Azoulay and Barker, {Alan F.} and Birring, {Surinder S.} and Fiona Blackhall and Bolser, {Donald C.} and hristopher Brightling and Priscilla Callahan-Lyon and Paul Davenport and Satoru Ebihara and {El Solh}, {Ali A.} and Patricio Escalante and Field, {Stephen K.} and Dina Fisher and French, {Cynthia T.} and Harding, {Susan M.} and Peter Gibson and Philip Gold and Anthony Harnden and Hill, {Adam T.} and Joanne Kavanagh and Keogh, {Karina A.} and Kefang Lai and Lane, {Andrew P.} and Madison, {J. Mark} and Malesker, {Mark A.} and Stuart Mazzone and Alex Molassoitis and Murad, {M. Hassan} and Mangala Narasimhan and Nguyen, {Huong Q.} and Peter Newcombe and Restrepo, {Marcos I.} and Mark Rosen and Ryu, {Jay H.} and Tarlo, {Susan M.} and Julie Turmel and Vertigan, {Anne E.} and Kelly Weir",
note = "Funding Information: Financial/nonfinancial disclosures: The authors have reported to CHEST the following: A. B. C. was an author of several of the papers included in this review, is an author and reviewer for Up to Date, was on the data safety monitoring board for a vaccine study (Glaxo), and has been an advisor for the study design of an unlicensed product (Merck). J. J. O. is on the Board of Directors for the American Board of Allergy and Immunology, is associate editor for the Annals of Allergy Watch, has been a reviewer for Up to Date, and has performed clinical research for Boehringer Ingelheim, Astra Zeneca, Glaxo, Medimmune and Novartis. B. K. R. is a member of scientific advisory boards for Merk and Quvium UK, Ltd. None declared (M. M. W., G. C. C., R. S. I.). Moreover, while RSI is the Editor in Chief of CHEST , the review and all editorial decisions regarding this manuscript were independently made by others. Other contributions: We are grateful to Nancy Harger, MLS, and Judy Nordberg, MLS, Education and Clinical Services Librarians working in the University of Massachusetts Medical School Library in Worcester, MA, who undertook all the searches for these systematic reviews. Role of sponsors: CHEST was the sole supporter of these guidelines, this article, and the innovations addressed within. Collaborators: Kenneth W. Altman, MD, PhD (Baylor College of Medicine, Houston, TX), Elie Azoulay, MD, PhD (University of Paris, Paris, France), Alan F. Barker, MD (Oregon Health & Science University, Portland, OR), Surinder S. Birring, MBChB, MD (Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, United Kingdom), Fiona Blackhall, MD, PhD (University of Manchester, Department of Medical Oncology, Manchester, England), Donald C. Bolser, PhD (College of Veterinary Medicine, University of Florida, Gainesville, FL), hristopher Brightling, MBBS, PhD, FCCP (University of Leicester, Glenfield Hospital, Leicester, United Kingdom), Priscilla Callahan-Lyon, MD (Adamstown, MD), Anne B. Chang, MBBS, PhD, MPH (Royal Children's Hospital, Queensland, Australia), Paul Davenport, PhD (Department of Physiological Sciences, University of Florida, Gainesville, FL), Satoru Ebihara, MD, PhD (Department of Rehabilitation Medicine, Toho University School of Medicine, Tokyo, Japan), Ali A. El Solh, MD, MPH (University at Buffalo, State University of New York, Buffalo, NY), Patricio Escalante, MD, MSc, FCCP (Mayo Clinic, Rochester, MN), Stephen K. Field, MD (University of Calgary, Calgary, AB, Canada), Dina Fisher, MD, MSc (University of Calgary, Respiratory Medicine, Calgary, AB, Canada), Cynthia T. French, PhD, FCCP (UMass Memorial Medical Center, Worcester, MA), Susan M. Harding, MD, FCCP (Division of Pulmonary, Allergy and Critical Care Medicine, Peter Gibson, MBBS (Hunter Medical Research Institute, New South Wales, Australia), Philip Gold, MD, MACP, FCCP (Loma Linda University, Loma Linda, CA), Anthony Harnden, MB ChB, MSc (University of Oxford, Oxford, England), Adam T. Hill, MB ChB, MD (Royal Infirmary and University of Edinburgh, Edinburgh, Scotland), Richard S. Irwin, MD, Master FCCP (UMass Memorial Medical Center, Worcester, MA), Joanne Kavanagh, MBChB, (Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, United Kingdom), Karina A. Keogh, MD (Mayo Clinic, Rochester, MN), Kefang Lai, MD, PhD (First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China), Andrew P. Lane, MD (Johns Hopkins University School of Medicine, Baltimore, MD), J. Mark Madison, MD, FCCP, (UMass Memorial Medical Center, Worcester, MA), Mark A. Malesker, PharmD, FCCP (Creighton University School of Pharmacy and Health Professions, Omaha, NE), Stuart Mazzone, PhD, FCCP (University of Queensland, Queensland, Australia), Alex Molassoitis, PhD, MSc, RN (Hong Kong Polytechnic University, Hong Kong, China, M. Hassan Murad, MD, MPH (Mayo Clinic, Rochester, MN), Mangala Narasimhan, DO, FCCP (Hofstra-Northwell Health, Manhasset, NY), Huong Q. Nguyen, PhD, RN (Kaiser Permanente, Pasadena, CA), Peter Newcombe, PhD (School of Psychology University of Queensland, Queensland, Australia), John Oppenheimer, MD (UMDNJ-Rutgers University), Marcos I. Restrepo, MD, MSc, FCCP (South Texas Veterans Health Care System, San Antonio), Mark Rosen, MD, Master FCCP (Icahn School of Medicine at Mount Sinai, New York, NY), Bruce Rubin, MEngr, MD, MBA (Virginia Commonwealth University, Richmond, VA), Jay H. Ryu, MD, FCCP (Mayo Clinic, Rochester, MN), Susan M. Tarlo, MBBS, FCCP (Toronto Western Hospital, Toronto, ON, Canada), Julie Turmel, PhD (Quebec Heart and Lung Institute, Laval University, Quebec), Anne E. Vertigan, PhD, MBA, BAppSc (SpPath) (John Hunter Hospital, New South Wales, Australia), Miles Weinberger, MD, FCCP (University of Iowa Hospitals and Clinics, Iowa City, IA), Kelly Weir, BSpThy, MSpPath, PhD, CPSP (Menzies Health Institute Queensland/Griffith and Gold Coast, Australia). Additional information: The e-Appendix and e-Figures can be found in the Supplemental Material section of the online article. Publisher Copyright: {\textcopyright} 2017",
year = "2017",
month = sep,
doi = "10.1016/j.chest.2017.06.006",
language = "English (US)",
volume = "152",
pages = "607--617",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "3",
}