Estimating age-specific breast cancer risks: A descriptive tool to identify age interactions

William F. Anderson, Rayna K. Matsuno, Mark E. Sherman, Jolanta Lissowska, Mitchell H. Gail, Louise A. Brinton, Xiaohong Yang, Beata Peplonska, Bingshu E. Chen, Philip S. Rosenberg, Nilanjan Chatterjee, Neonila Szeszenia-Da̧browska, Alicja Bardin-Mikolajczak, Witold Zatonski, Susan S. Devesa, Montserrat García-Closas

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Objective: Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues. Method: Using a population-based case-control study in Poland (2000-2003) of 2,386 incident breast cancer cases and 2,502 control subjects aged 25-74 years, we estimated age-specific breast cancer incidence rates according to risk factors. Results: Breast cancer risks were elevated among women with positive family history (FH), younger age at menarche, older age at first full-term birth, nulliparity, exogenous hormonal usage, and reduced physical activity (PA). Notwithstanding overall risks, we observed statistically significant quantitative (non-crossover) and qualitative (crossover) age interactions for all risk factors except for FH and PA. For example, nulliparity compared to parity reduced breast cancer risk among women ages 25-39 years then rates crossed or reversed, after which nulliparity increased relative risks among women ages 40-74 years. Conclusion: Though quantitative age interactions could be expected, qualitative interactions were somewhat counterintuitive. If confirmed in other populations, qualitative interactions for a continuous covariate such as age will be difficult to reconcile in a sequential (multistep or monolithic) 'stochastic' breast cancer model. Alternatively, the reversal of relative risks among younger and older women suggests subgroup heterogeneity with different etiologic mechanisms for early-onset and late-onset breast cancer types.

Original languageEnglish (US)
Pages (from-to)439-447
Number of pages9
JournalCancer Causes and Control
Issue number4
StatePublished - May 2007


  • Absolute risks
  • Odds ratio
  • Population-based case-control study
  • Rate ratios
  • Relative risks

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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