Epilepsy in children-when should we think neurometabolic disease?

Radhika Dhamija, Marc C. Patterson, Elaine C. Wirrell

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Seizures are often the first manifestation of central nervous system dysfunction and are common in many inborn errors of metabolism, especially in neonates, infants, and children. A high index of suspicion is required to diagnose inborn errors of metabolism as the cause of seizures. It is also important to recognize these metabolic disorders early, as specific disease-modifying treatments are available for some with favorable long-term outcomes. This review discusses the classification of metabolic disorders as a cause of seizures based on pathogenesis and age and proposes a tiered approach for cost-effective diagnosis of metabolic disorders.

Original languageEnglish (US)
Pages (from-to)663-671
Number of pages9
JournalJournal of child neurology
Issue number5
StatePublished - May 1 2012


  • epilepsy
  • pathogenesis metabolism
  • seizures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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