Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors

Kazuki Sumiyama, Christopher J. Gostout, Elizabeth Rajan, Timothy A. Bakken, Jodie L. Deters, Mary A. Knipschield

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Background: A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model. Objectives: Six pigs. Design: Short-term survival animal study. Settings: Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall. Interventions: Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation. Main Outcome Measurements: One week follow-up endoscopy and necropsy were performed. Results: Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations. Conclusions: Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalGastrointestinal endoscopy
Issue number1
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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