Emergency department hyperglycemia as a predictor of early mortality and worse functional outcome after intracerebral hemorrhage

Latha G. Stead, Anunaya Jain, M. Fernanda Bellolio, Adetolu Odufuye, Rachel M. Gilmore, Alejandro Rabinstein, Raghav Chandra, Ravneet Dhillon, Veena Manivannan, Luis A. Serrano, Neeraja Yerragondu, Balavani Palamari, Minal Jain, Wyatt W. Decker

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Background: We have previously reported the association of hyperglycemia and mortality after ischemic stroke. This study attempts to answer the hypothesis, if hyperglycemia at arrival, is associated with early mortality and functional outcome in patients with acute non-traumatic intracerebral hemorrhage (ICH). Methods: The study cohort consisted of 237 patients who presented to the ED with ICH and had blood glucose measured on ED presentation. The presence of hyperglycemia on presentation was correlated with outcome measures including volume of hematoma, intraventricular extension of hematoma (IVE), stroke severity, functional outcome at discharge, and date of death. Results: Of the cohort of 237 patients, a total of 47 patients had prior history of Diabetes Mellitus (DM). Median blood glucose at presentation was 140 mg/dl (Inter-quartile range 112-181 mg/dl). DM patients had higher glucose levels on arrival (median 202 mg/dl for DM vs. 132.5 mg/dl for non-DM, P < 0.0001). Higher blood glucose at ED arrival was associated with early mortality in both non-diabetics and diabetics (P < 0.0001). Higher blood glucose was associated with poor functional outcome in non-DM patients (P < 0.0001) but not in DM patients (P = 0.268). In the logistic regression model, after adjustment for stroke severity, hematoma volume, and IVE of hemorrhage, higher initial blood glucose was a significant predictor of death (P = 0.0031); as well as bad outcome in non-DM patients (P = 0.004). Conclusions: Hyperglycemia on presentation in non-diabetic patients is an independent predictor of early mortality and worse functional outcome in patients with intracerebral hemorrhage.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalNeurocritical care
Issue number1
StatePublished - Aug 2010


  • Diabetes
  • Glucose
  • Hyperglycemia
  • Intracerebral hemorrhage
  • Mortality
  • Outcomes research
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Emergency department hyperglycemia as a predictor of early mortality and worse functional outcome after intracerebral hemorrhage'. Together they form a unique fingerprint.

Cite this