Elution of High Dose Amphotericin B Deoxycholate From Polymethylmethacrylate

Matthew T. Houdek, Kerryl E. Greenwood-Quaintance, Mark E. Morrey, Robin Patel, Arlen D. Hanssen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Fungal periprosthetic joint infections are rare, devastating complications of arthroplasty. There is conflicting evidence as to the efficacy of amphotericin B elution from cement spacers. The purpose of this study was to determine whether concentrations of amphotericin B released from bone cement over time would be efficacious in treating a periprosthetic infection. A continuous flow chamber was used to evaluate the in vitro release of amphotericin from cement beads containing 7.5% amphotericin. Following polymerization, 3.3% of the initially loaded amphotericin B was detected. The peak mean concentration eluted from the bone cement was 0.33 μg/mL at 8 hours. The AUC0-24 was 2.79 μg/mL/h; 0.20% of the amphotericin B was released. In conclusion, amphotericin B is released from bone cement at a clinically useful concentration.

Original languageEnglish (US)
Pages (from-to)2308-2310
Number of pages3
JournalJournal of Arthroplasty
Issue number12
StatePublished - Dec 1 2015


  • Amphotericin
  • Cement spacer
  • Drug elution
  • Fungal infection
  • Prosthetic joint infection

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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