Electromechanical Activation Sequence in Normal Heart

Partho P. Sengupta, Fernando Tondato, Bijoy K. Khandheria, Marek Belohlavek, Arshad Jahangir

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


This article summarizes the recent experimental and theoretic data regarding the normal electromechanical activation sequence of the left ventricle (LV). First, the cardiac electrical sequence is presented with a brief insight into the wave front of electrical activation that develops from the organized transmural spread of action potentials. Second, the regional heterogeneity in electromechanical coupling and myofiber stretch-shortening kinematics are presented. Finally, the transmural shortening and lengthening sequences are linked with the myofiber architecture of the left ventricular wall to explain the global three-dimensional twisting deformation of the LV. Integrating the electrical and mechanical domains of myocardial function provides vital insights into the macroscopic physiologic behavior of a beating heart.

Original languageEnglish (US)
Pages (from-to)303-314
Number of pages12
JournalHeart Failure Clinics
Issue number3
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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