Effects of Synovial Interposition on Healing in a Canine Tendon Explant Culture Model

Jun Ikeda, Chunfeng Zhao, Steven L. Moran, Kai Nan An, Peter C. Amadio

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Purpose: To investigate whether synovium interposition between repaired tendon ends can integrate into the tendon repair and improve tendon healing strength in a canine tendon explant culture model. Methods: We used 80 flexor digitorum profundus tendons from 10 mixed-breed dogs for this study. The flexor digitorum profundus tendons were assigned to 2 groups: repaired tendons with synovium implanted between the cut tendon ends and repaired tendons without any implantation between the tendon ends. The repaired tendons were cultured for either 2 or 4 weeks and then assessed mechanically for rupture strength and histology. Results: The strength of the repaired tendons with the synovium interposition was significantly higher (p < .001) than the repaired tendons without interposition at both 2 and 4 weeks. The strength of the repaired tendons at 4 weeks was significantly higher than that at 2 weeks in both groups. Conclusions: Interpositional synovial grafts have the potential to accelerate tendon healing when they are implanted at the repair site. The exact mechanism of this effect remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)1153-1159
Number of pages7
JournalJournal of Hand Surgery
Issue number7
StatePublished - Jul 2010


  • Flexor tendon
  • healing
  • in vitro
  • mechanical test
  • synovial interposition

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


Dive into the research topics of 'Effects of Synovial Interposition on Healing in a Canine Tendon Explant Culture Model'. Together they form a unique fingerprint.

Cite this