Effects of hyperoxia on the developing airway and pulmonary vasculature

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Although it is necessary and part of standard practice, supplemental oxygen (40–90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages16
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Alveologenesis
  • Heme oxygenase-1
  • Hyperoxia
  • Hypoxia inducible factor nitric oxide
  • Lung development
  • Nuclear factor E2-related factor 2
  • Pulmonary vasculogenesis redox signaling
  • Soluble guanylate cyclase
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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