Effects of GLP-1 on appetite and weight

Meera Shah, Adrian Vella

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations


Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene which is expressed in the α-cells of the pancreas, the L-cells of the intestine, and neurons located in the caudal brainstem and hypothalamus. GLP-1 is of relevance to appetite and weight maintenance because it has actions on the gastrointestinal tract as well as the direct regulation of appetite. It delays gastric emptying and gut motility in humans. In addition, interventricular injections of GLP-1 inhibit food intake, independent of the presence of food in the stomach or gastric emptying. Peripherally administered GLP-1 also affects the central regulation of feeding. It is therefore the synergistic actions of GLP-1 in the gut and brain, acting on both central and peripheral receptors that seem responsible for the effects of the hormone on satiety.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalReviews in Endocrine and Metabolic Disorders
Issue number3
StatePublished - Sep 2014


  • Appetite
  • Bariatric surgery
  • Gastric accommodation
  • Gastric emptying
  • Satiety

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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