Effective gastric acid suppression after oral administration of enteric-coated omeprazole granules

Muhammad A. Mohiuddin, K. G. Pursnani, David A. Katzka, R. M. Gideon, June A. Castell, Donald O. Castell

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Omeprazole is inactivated by exposure to gastric acid and is formulated as a gelatin capsule containing enteric-coated granules that release the drug in alkaline medium. In clinical situations where patients are unable to take the capsule orally, the optimum means of administration is uncertain. Eleven normal volunteers were given omeprazole 20 mg every day for one week before breakfast in random order as either a 20-mg capsule with water or free enteric-coated granules with either 8 oz of orange juice, 8 oz of water with 2 Alka-Seltzer antacid tablets (aspirin free), or 1 teaspoon of apple sauce. On day 7 of each regimen, an 8-hr intragastric pH study was performed following omeprazole 20 mg and standard breakfast. The median percentage of time of gastric acid pH > 4 after an omeprazole capsule was 68.5 (25-100); after granules with orange juice 59 (43-100); after granules in Alka-Seltzer solution 63 (31-100), and after granules in apple sauce 65 (30-99), with no significant differences (ANOVA). The time for the gastric pH to reach <4' after having been above was also similar for all four regimens (ANOVA). Omeprazole granules administered orally in a variety of ways achieve gastric acid suppression as effectively as the intact capsule.

Original languageEnglish (US)
Pages (from-to)715-719
Number of pages5
JournalDigestive diseases and sciences
Issue number4
StatePublished - 1997


  • acid suppression
  • gastric secretion
  • omeprazole

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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