Effect of Megestrol Acetate on the Human Pituitary-Adrenal Axis

CHARLES L. LOPRINZI; MICHAEL D. JENSEN; NAI SIANG JIANG; DANIEL J. SCHAID

doi:10.1016/S0025-6196(12)61145-8

Effect of Megestrol Acetate on the Human Pituitary-Adrenal Axis

CHARLES L. LOPRINZI, MICHAEL D. JENSEN, NAI SIANG JIANG, DANIEL J. SCHAID

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Abstract

A few previous reports have suggested that megestrol acetate, a synthetic progestational agent frequently used as an antineoplastic drug, suppresses serum cortisol concentrations in humans. To explore this concept further, we prospectively performed several measurements of the pituitary-adrenal axis in patients receiving megestrol acetate (160 or 800 mg/day). The data from these evaluations demonstrate that megestrol acetate reversibly decreases serum cortisol concentrations in humans and that this effect seems to originate from a suppression of the pituitary-adrenal axis. Additional studies should be conducted to determine the implications of the low levels of serum cortisol.

Original language	English (US)
Pages (from-to)	1160-1162
Number of pages	3
Journal	Mayo Clinic proceedings
Volume	67
Issue number	12
DOIs	https://doi.org/10.1016/S0025-6196(12)61145-8
State	Published - Jan 1 1992

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Medicine(all)

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abstract = "A few previous reports have suggested that megestrol acetate, a synthetic progestational agent frequently used as an antineoplastic drug, suppresses serum cortisol concentrations in humans. To explore this concept further, we prospectively performed several measurements of the pituitary-adrenal axis in patients receiving megestrol acetate (160 or 800 mg/day). The data from these evaluations demonstrate that megestrol acetate reversibly decreases serum cortisol concentrations in humans and that this effect seems to originate from a suppression of the pituitary-adrenal axis. Additional studies should be conducted to determine the implications of the low levels of serum cortisol.",

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AU - SCHAID, DANIEL J.

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AB - A few previous reports have suggested that megestrol acetate, a synthetic progestational agent frequently used as an antineoplastic drug, suppresses serum cortisol concentrations in humans. To explore this concept further, we prospectively performed several measurements of the pituitary-adrenal axis in patients receiving megestrol acetate (160 or 800 mg/day). The data from these evaluations demonstrate that megestrol acetate reversibly decreases serum cortisol concentrations in humans and that this effect seems to originate from a suppression of the pituitary-adrenal axis. Additional studies should be conducted to determine the implications of the low levels of serum cortisol.

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Effect of Megestrol Acetate on the Human Pituitary-Adrenal Axis

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