Effect of Cystone® on urinary composition and stone formation over a one year period

S. B. Erickson, T. J. Vrtiska, J. C. Lieske

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Kidney stones are a common problem for which inadequate prevention exists. We recruited ten recurrent kidney stone formers with documented calcium oxalate stones into a two phased study to assess safety and effectiveness of Cystone®, an herbal treatment for prevention of kidney stones. The first phase was a randomized double-blinded 12 week cross over study assessing the effect of Cystone® vs. placebo on urinary supersaturation. The second phase was an open label one year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. Results revealed no statistically significant effect of Cystone® on urinary composition short (6 weeks) or long (52 weeks) term. Average renal stone burden increased rather than decreased on Cystone®. Therefore, this study does not support the efficacy of Cystone® to treat calcium oxalate stone formers. Future studies will be needed to assess effects on stone passage, or on other stone types.

Original languageEnglish (US)
Pages (from-to)863-867
Number of pages5
Issue number10
StatePublished - Jul 15 2011


  • Computerized tomography
  • Cystone
  • Herb
  • Kidney calculi
  • Nephrolithiasis
  • Quantitative CT
  • Supersaturation

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine


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