Effect of central sympathectomy on gastric and small intestinal myoelectric activity and plasma motilin concentrations in the dog

Gordon L. Telford; Vay Liang W. Go; Joseph H. Szurszewski

doi:10.1016/0016-5085(85)90198-2

Effect of central sympathectomy on gastric and small intestinal myoelectric activity and plasma motilin concentrations in the dog

Gordon L. Telford, Vay Liang W. Go, Joseph H. Szurszewski

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Using a canine model, we studied fed and fasting gastric and small intestinal myoelectric activity and plasma motilin concentrations before and after transection of the spinal cord between the second and third thoracic segments. In sham-operated dogs, migrating complexes returned to normal by the second day after operation. Immediately after spinal cord transection, migrating complexes cycled in jejunum and ileum but not in the stomach and duodenum. After 11 and 15 days, migrating complexes returned to the duodenum and stomach, respectively. Plasma motilin concentrations did not cycle in animals without duodenal migrating complexes but returned to a normal cyclical pattern when duodenal migrating complexes returned. Feeding interrupted migrating complexes after cord transection and sham operation. The data observed in animals after 15 days suggest that myoelectric activity in fasted dogs and conversion of the fasted to the fed state of myoelectric activity are not under the control of supraspinal, sympathetic pathways.

Original language	English (US)
Pages (from-to)	989-995
Number of pages	7
Journal	Gastroenterology
Volume	89
Issue number	5
DOIs	https://doi.org/10.1016/0016-5085(85)90198-2
State	Published - Nov 1985

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/0016-5085(85)90198-2

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title = "Effect of central sympathectomy on gastric and small intestinal myoelectric activity and plasma motilin concentrations in the dog",

abstract = "Using a canine model, we studied fed and fasting gastric and small intestinal myoelectric activity and plasma motilin concentrations before and after transection of the spinal cord between the second and third thoracic segments. In sham-operated dogs, migrating complexes returned to normal by the second day after operation. Immediately after spinal cord transection, migrating complexes cycled in jejunum and ileum but not in the stomach and duodenum. After 11 and 15 days, migrating complexes returned to the duodenum and stomach, respectively. Plasma motilin concentrations did not cycle in animals without duodenal migrating complexes but returned to a normal cyclical pattern when duodenal migrating complexes returned. Feeding interrupted migrating complexes after cord transection and sham operation. The data observed in animals after 15 days suggest that myoelectric activity in fasted dogs and conversion of the fasted to the fed state of myoelectric activity are not under the control of supraspinal, sympathetic pathways.",

author = "Telford, {Gordon L.} and Go, {Vay Liang W.} and Szurszewski, {Joseph H.}",

note = "Funding Information: Received November 19. 1984. Accepted April 16, 1985. Address requests for reprints to: Gordon L. Telford, Department of Surgery, The Medical College of Wisconsin. West Wisconsin Avenue, Milwaukee, Wisconsin 53226. This work was supported by grants AM 17632 and AM from the National Institutes of Health. The authors thank Dr. C. Frisk, staff veterinarian, C. Schram for their assistance. 0 1985 by the American Gastroenterological 0016-5085/85/$3,30",

year = "1985",

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doi = "10.1016/0016-5085(85)90198-2",

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AU - Telford, Gordon L.

AU - Go, Vay Liang W.

AU - Szurszewski, Joseph H.

N1 - Funding Information: Received November 19. 1984. Accepted April 16, 1985. Address requests for reprints to: Gordon L. Telford, Department of Surgery, The Medical College of Wisconsin. West Wisconsin Avenue, Milwaukee, Wisconsin 53226. This work was supported by grants AM 17632 and AM from the National Institutes of Health. The authors thank Dr. C. Frisk, staff veterinarian, C. Schram for their assistance. 0 1985 by the American Gastroenterological 0016-5085/85/$3,30

PY - 1985/11

Y1 - 1985/11

N2 - Using a canine model, we studied fed and fasting gastric and small intestinal myoelectric activity and plasma motilin concentrations before and after transection of the spinal cord between the second and third thoracic segments. In sham-operated dogs, migrating complexes returned to normal by the second day after operation. Immediately after spinal cord transection, migrating complexes cycled in jejunum and ileum but not in the stomach and duodenum. After 11 and 15 days, migrating complexes returned to the duodenum and stomach, respectively. Plasma motilin concentrations did not cycle in animals without duodenal migrating complexes but returned to a normal cyclical pattern when duodenal migrating complexes returned. Feeding interrupted migrating complexes after cord transection and sham operation. The data observed in animals after 15 days suggest that myoelectric activity in fasted dogs and conversion of the fasted to the fed state of myoelectric activity are not under the control of supraspinal, sympathetic pathways.

AB - Using a canine model, we studied fed and fasting gastric and small intestinal myoelectric activity and plasma motilin concentrations before and after transection of the spinal cord between the second and third thoracic segments. In sham-operated dogs, migrating complexes returned to normal by the second day after operation. Immediately after spinal cord transection, migrating complexes cycled in jejunum and ileum but not in the stomach and duodenum. After 11 and 15 days, migrating complexes returned to the duodenum and stomach, respectively. Plasma motilin concentrations did not cycle in animals without duodenal migrating complexes but returned to a normal cyclical pattern when duodenal migrating complexes returned. Feeding interrupted migrating complexes after cord transection and sham operation. The data observed in animals after 15 days suggest that myoelectric activity in fasted dogs and conversion of the fasted to the fed state of myoelectric activity are not under the control of supraspinal, sympathetic pathways.

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Effect of central sympathectomy on gastric and small intestinal myoelectric activity and plasma motilin concentrations in the dog

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