Effect of Body Mass Index on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Carolyn M. Larsen, Caroline A. Ball, Virginia B. Hebl, Kevin C. Ong, Konstantinos C. Siontis, Thomas P Olson, Michael John Ackerman, Steve R. Ommen, Thomas G. Allison, Jeffrey B. Geske

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The objective of this study was to evaluate the relation between body mass index (BMI), exercise capacity, and symptoms in patients with hypertrophic cardiomyopathy (HC) and to utilize results of cardiopulmonary exercise tests (CPX) and transthoracic echocardiograms to understand the mechanism(s) of reduced exercise capacity across body mass index groups. Over a 6-year period, 510 consecutive patients with HC seen at a tertiary referral center underwent (CPX) and a transthoracic echocardiogram. Increasing BMI was associated with decreased exercise capacity as assessed by peak VO2 (ml/kg/min). However, the prevalence of cardiac impairment did not vary by BMI group. In conclusion, these findings suggest that in some patients with hypertrophic cardiomyopathy, cardiac impairment is not the primary cause of exercise limitation and weight loss may result in improved exercise capacity.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalAmerican Journal of Cardiology
Issue number1
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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