Effect of basal epicardial tone on endothelium-independent coronary flow reserve measurement

David Hasdai, David R. Holmes, Stuart T. Higano, Amir Lerman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Increased basal epicardial tone may attenuate the coronary flow reserve (CFR) by causing vasodilatation of resistance vessels. We examined the effect of basal epicardial tone on the endothelium-independent CFR measurements in subjects with nonobstructive coronary disease. Patients underwent evaluation of endothelium-independent CFR using adenosine (18-36 μg) and endothelium- dependent CFR using acetylcholine (10-6M-10-4M), both administered intracoronary. CFR to adenosine, presented as the ratio of Doppler flow velocities post- and pre-adenosine, was measured at baseline and after intracoronary nitroglycerin (200 μg). Nitroglycerin increased the coronary artery diameter by 19.7 ± 2.5%, and decreased the coronary vascular resistance from 3.0 ± 0.2 mm Hg/ml/min to 1.8 ± 0.1 mm Hg/ml/min (p < 0.0001). The response to adenosine at baseline and after nitroglycerin was similar (CFR ratio of 2.52 ± 0.09 and 2.57 ± 0.10, respectively, p = NS). The effect of nitroglycerin on the response to adenosine did not correlate with coronary endothelial function (r2 = 0.06, p = 0.13). The basal epicardial tone does not affect CFR measurements in patients with angina and nonobstructive coronary disease.

Original languageEnglish (US)
Pages (from-to)392-396
Number of pages5
JournalCatheterization and cardiovascular diagnosis
Issue number4
StatePublished - Aug 1998


  • Acetylcholine
  • Adenosine
  • Coronary artery disease
  • Coronary flow reserve
  • Doppler

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Effect of basal epicardial tone on endothelium-independent coronary flow reserve measurement'. Together they form a unique fingerprint.

Cite this