EBV-Positive Plasmacytomas Involving a Nasopharyngeal Angiofibroma in an Adolescent

Rachel Mariani, Rebecca L. King, Huifei Liu

Research output: Contribution to journalArticlepeer-review


We report comprehensive characterization of an unusual collision tumor comprising extramedullary plasmacytomas and nasopharyngeal angiofibroma in a pediatric patient, which has yet to be reported. Histologically, the nasopharyngeal angiofibroma showed typical morphology with a diffuse, dense plasmacytic infiltrate in the stroma. The neoplastic plasma cells showed a spectrum of well-differentiated, plasmablastic, and anaplastic morphology, Epstein-Barr virus encoded RNA (EBER) positivity, and aberrant immunophenotype. Fluorescence in situ hybridization using a plasma cell myeloma targeted panel detected gains of 1q21.3 (CKS1B, x3), 3q27 (BCL6, x4), and 11q22.3 (ATM, x3), but no rearrangement of ALK and MYC. A 50-gene next generation sequencing lymphoma panel failed to detect any pathogenic mutation. Plasmacytoma with EBER positivity and plasmablastic morphology must be distinguished from plasmablastic lymphoma due to different clinical management and prognosis. This case highlights the importance of a thorough pathological evaluation of a mass lesion with synchronous neoplastic processes.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalPediatric and Developmental Pathology
Issue number3
StatePublished - Jun 2021


  • Epstein-Barr virus encoded RNA
  • anaplastic
  • nasopharyngeal angiofibroma
  • plasmablastic
  • plasmacytoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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