Early detection of pancreatic cancer

Sushil Kumar Garg, Suresh T. Chari

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose of reviewPancreatic cancer is the third leading cause of cancer death and with a dismal 5-year survival of 10%. Poor survival of pancreatic cancer is mostly due to its presentation and diagnosis at a late stage. The present article aims to update clinicians with recent progress in the field of early detection of pancreatic cancer.Recent findingsPancreatic cancer screening is not recommended in the general population due to its low prevalence. In this review, we discuss high-risk groups for pancreatic cancer, including inherited predisposition to pancreatic cancer, new-onset diabetes, mucinous pancreatic cyst, and chronic pancreatitis. We discuss methods of enrichment of high-risk groups with clinical models using electronic health records and biomarkers. We also discuss improvements in imaging modalities and emerging role of machine learning and artificial intelligence in the field of imaging and biomarker to aid in early identification of pancreatic cancer.SummaryThere are still vast challenges in the field of early detection of pancreatic cancer. We need to develop noninvasive prediagnostic validated biomarkers for longitudinal surveillance of high-risk individuals and imaging modalities that can identify pancreatic cancer early.

Original languageEnglish (US)
Pages (from-to)456-461
Number of pages6
JournalCurrent Opinion in Gastroenterology
Issue number5
StatePublished - Sep 1 2020


  • familial pancreatic cancer
  • new-onset diabetes
  • pancreatic cancer screening
  • pancreatic cyst

ASJC Scopus subject areas

  • Gastroenterology


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