Dynamin as a mover and pincher during cell migration and invasion

Anne E. Kruchten, Mark A. McNiven

Research output: Contribution to journalComment/debatepeer-review

103 Scopus citations


The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell motility. Its role in actin polymerization, membrane deformation and vesiculation, and focal adhesion dynamics are all important for this process, and the new findings provide exciting directions for studies of this ubiquitous and diverse protein family.

Original languageEnglish (US)
Pages (from-to)1683-1690
Number of pages8
JournalJournal of cell science
Issue number9
StatePublished - May 1 2006


  • Cell motility
  • Dynamin
  • Invasion
  • Migration

ASJC Scopus subject areas

  • Cell Biology


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