Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data

W. A. Kelly; Ronald J Marler; J. H. Weikel

doi:10.3109/10915819309140618

Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data

W. A. Kelly, Ronald J Marler, J. H. Weikel

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Abstract

Leiomyomas developed in the ovarian suspensory ligament (costo-uterine muscle) of rats after long-term treatment with several beta₂-adrenoceptor stimulant drugs. The response was evidently related to excessive adrenergic stimulation of a tissue with a high density of ä₂-receptors; was inhibited by ä blockade; and was directly related to in vitro pharmacologic potency. Tumor development was dependent on continuous administration of adequate dosages to a susceptible strain of rat. Histologically, all tumors were benign and none were malignant. After many years of clinical experience, there are no known reports of this response in human patients receiving ä₂-adrenoceptor-stimulant drugs.

Original language	English (US)
Pages (from-to)	13-22
Number of pages	10
Journal	International Journal of Toxicology
Volume	12
Issue number	1
DOIs	https://doi.org/10.3109/10915819309140618
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Toxicology

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title = "Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data",

abstract = "Leiomyomas developed in the ovarian suspensory ligament (costo-uterine muscle) of rats after long-term treatment with several beta2-adrenoceptor stimulant drugs. The response was evidently related to excessive adrenergic stimulation of a tissue with a high density of {\"a}2-receptors; was inhibited by {\"a} blockade; and was directly related to in vitro pharmacologic potency. Tumor development was dependent on continuous administration of adequate dosages to a susceptible strain of rat. Histologically, all tumors were benign and none were malignant. After many years of clinical experience, there are no known reports of this response in human patients receiving {\"a}2-adrenoceptor-stimulant drugs.",

author = "Kelly, {W. A.} and Marler, {Ronald J} and Weikel, {J. H.}",

year = "1993",

doi = "10.3109/10915819309140618",

language = "English (US)",

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journal = "International Journal of Toxicology",

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AU - Kelly, W. A.

AU - Marler, Ronald J

AU - Weikel, J. H.

PY - 1993

Y1 - 1993

N2 - Leiomyomas developed in the ovarian suspensory ligament (costo-uterine muscle) of rats after long-term treatment with several beta2-adrenoceptor stimulant drugs. The response was evidently related to excessive adrenergic stimulation of a tissue with a high density of ä2-receptors; was inhibited by ä blockade; and was directly related to in vitro pharmacologic potency. Tumor development was dependent on continuous administration of adequate dosages to a susceptible strain of rat. Histologically, all tumors were benign and none were malignant. After many years of clinical experience, there are no known reports of this response in human patients receiving ä2-adrenoceptor-stimulant drugs.

AB - Leiomyomas developed in the ovarian suspensory ligament (costo-uterine muscle) of rats after long-term treatment with several beta2-adrenoceptor stimulant drugs. The response was evidently related to excessive adrenergic stimulation of a tissue with a high density of ä2-receptors; was inhibited by ä blockade; and was directly related to in vitro pharmacologic potency. Tumor development was dependent on continuous administration of adequate dosages to a susceptible strain of rat. Histologically, all tumors were benign and none were malignant. After many years of clinical experience, there are no known reports of this response in human patients receiving ä2-adrenoceptor-stimulant drugs.

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Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data

Abstract

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