Doppler evaluation of results of percutaneous aortic balloon valvuloplasty in calcific aortic stenosis

R. A. Nishimura, D. R. Holmes, G. S. Reeder, T. A. Orszulak, J. F. Bresnahan, D. M. Ilstrup, A. J. Tajik

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


To evaluate the short-term results of percutaneous aortic balloon valvuloplasty, 55 consecutive elderly patients with symptomatic, severe aortic stenosis who were at high risk for surgical intervention underwent the procedure, with follow-up by clinical evaluation and Doppler echocardiography. Over a mean follow-up of 6.2 months, there were three early deaths (<30 days) and eight late deaths. Nine patients underwent subsequent aortic valve surgery, and four had repeat balloon valvuloplasty. Doppler echocardiography revealed a reduction in aortic valve mean gradient from 48 ± 18 to 33 ± 12 mm Hg after the procedure (p < 0.0001) but a return to 46 ± 16 mm Hg at follow-up (p < 0.05). The aortic valve area increased from 0.54 ± 0.15 to 0.85 ± 0.23 cm2 after the procedure (p < 0.0001), but there was a significant decrease to 0.67 ± 0.19 cm2 at follow-up (p < 0.05). Of patients free of aortic valve operation or death after 30 days after the procedure, 76% were severely symptomatic before the procedure as compared with 38% at follow-up. In patients undergoing percutaneous aortic balloon valvuloplasty, there is a continued high short-term mortality and a significant incidence of restenosis over short-term follow-up. Nontheless, a subset of patients do experience sustained clinical improvement from this procedure.

Original languageEnglish (US)
Pages (from-to)791-799
Number of pages9
Issue number4 I
StatePublished - 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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