Dolutegravir, an HIV integrase inhibitor for the treatment of HIV infection

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1 Scopus citations


Dolutegravir, a next-generation integrase strand transfer inhibitor, was recently approved by the United States Foodand Drug Administration to treat antiretroviral therapy-naive as well as treatment-experienced HIV-infected individuals, including those who have been treated with other integrase strand transfer inhibitors. Dolutegravir is the first stand-alone agent in its class, with a pharmacokinetic profile that allows once-daily administration without the requirement for pharmacologic boosting. It is metabolized primarily by UDP-glucuronosyltransferase 1-1 (UGT1A1) and is expected to have a limited propensity for drug-druginteractions. Furthermore, dolutegravir retains significant virologic activity against raltegravir- or elvitegravir-associated HIV-1 resistance mutations.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalDrugs of Today
Issue number1
StatePublished - Jan 2014


  • Anti-HIV agents
  • Antiretroviral-naive
  • Dolutegravir
  • GSK-1349572
  • HIV integrase inhibitors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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