Diminished survival in asymptomatic primary biliary cirrhosis. A prospective study

Kumaravelu Balasubramaniam, Patricia M. Grambsch, Russell H. Wiesner, Keith D. Lindor, E. Rolland Dickson

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Data from 73 asymptomatic patients with primary biliary cirrhosis were analyzed to determine clinical course and long-term survival. Of these, 44 entered a d-penicillamine treatment trial; 29 qualified but chose not to participate. Median follow-up was 7.6 yr (range, 2.8-12.2 yr). Liver biopsy at the initial visit showed advanced disease (fibrosis, cirrhosis) in 61% of the patients. During prospective clinical followup, which was available for 37 of the 44 study patients, one or more symptoms of liver disease developed in 33 (89%); esophageal varices were found in 15 (41%), and histologic progression to cirrhosis was found in 20 (67%) of the 30 precirrhotic patients. Significant (p < 0.01) biochemical progression was reflected by a decrease in mean serum albumin concentrations and an increase in mean serum bilirubin levels in 32 patients followed for 4-6 yr. Survival data were available for all 73 patients; 17 died (11 secondary to liver failure), and 1 underwent liver transplantation. These patients had a 4-fold increase in mortality rate (p < 0.001) compared with the U.S. population matched for age, race, and sex.

Original languageEnglish (US)
Pages (from-to)1567-1571
Number of pages5
Issue number6
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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