Diffuse leukoencephalopathy with spheroids presenting as primary progressive aphasia

Carly Oboudiyat, Eileen H. Bigio, Borna Bonakdarpour, Matt C. Baker, Rosa Rademakers, Sandra Weintraub, M. Marsel Mesulam

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


A 52-year-old right-handed man reported 2 years of progressive word-finding difficulties. He noticed hesitations when retrieving words and difficulty writing and calculating while working in his carpentry business. He was taking pravastatin for hyperlipidemia. Memantine was started prior to our clinical evaluation, and had no measurable effect. He had a great aunt with late-life amnestic dementia, his father died at age 59 years from lung cancer, and his mother died at age 75 of unknown causes. He had 18 years of education and no history of learning disabilities.

Original languageEnglish (US)
Pages (from-to)652-653
Number of pages2
Issue number7
StatePublished - Aug 18 2015

ASJC Scopus subject areas

  • Clinical Neurology


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