Differential role of PTEN phosphatase in chemotactic growth cone guidance

Steven J. Henle; Lucas P. Carlstrom; Thomas R. Cheever; John R. Henley

doi:10.1074/jbc.C113.487066

Differential role of PTEN phosphatase in chemotactic growth cone guidance

Steven J. Henle, Lucas P. Carlstrom, Thomas R. Cheever, John R. Henley

Neurosurgery

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: The phosphatase PTEN is implicated in suppressing neuroregeneration following injury. Results: Chemorepulsion of axons by distinct cues, but not chemoattraction, correlates with PTEN activity, depression of phosphatidylinositol signaling, and remodeling of integrin adhesions. Conclusion: PTEN mediates chemorepulsion selectively. Significance: Suppressing PTEN activity may block repulsion by negative cues after injury while permitting attractive guidance of regenerating axons.

Original language	English (US)
Pages (from-to)	20837-20842
Number of pages	6
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.C113.487066
State	Published - Jul 19 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Differential role of PTEN phosphatase in chemotactic growth cone guidance",

abstract = "Background: The phosphatase PTEN is implicated in suppressing neuroregeneration following injury. Results: Chemorepulsion of axons by distinct cues, but not chemoattraction, correlates with PTEN activity, depression of phosphatidylinositol signaling, and remodeling of integrin adhesions. Conclusion: PTEN mediates chemorepulsion selectively. Significance: Suppressing PTEN activity may block repulsion by negative cues after injury while permitting attractive guidance of regenerating axons.",

author = "Henle, {Steven J.} and Carlstrom, {Lucas P.} and Cheever, {Thomas R.} and Henley, {John R.}",

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T1 - Differential role of PTEN phosphatase in chemotactic growth cone guidance

AU - Henle, Steven J.

AU - Carlstrom, Lucas P.

AU - Cheever, Thomas R.

AU - Henley, John R.

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: The phosphatase PTEN is implicated in suppressing neuroregeneration following injury. Results: Chemorepulsion of axons by distinct cues, but not chemoattraction, correlates with PTEN activity, depression of phosphatidylinositol signaling, and remodeling of integrin adhesions. Conclusion: PTEN mediates chemorepulsion selectively. Significance: Suppressing PTEN activity may block repulsion by negative cues after injury while permitting attractive guidance of regenerating axons.

AB - Background: The phosphatase PTEN is implicated in suppressing neuroregeneration following injury. Results: Chemorepulsion of axons by distinct cues, but not chemoattraction, correlates with PTEN activity, depression of phosphatidylinositol signaling, and remodeling of integrin adhesions. Conclusion: PTEN mediates chemorepulsion selectively. Significance: Suppressing PTEN activity may block repulsion by negative cues after injury while permitting attractive guidance of regenerating axons.

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Differential role of PTEN phosphatase in chemotactic growth cone guidance

Abstract

ASJC Scopus subject areas

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