Differential health benefits of weight loss in upper-body and lower-body obese women

Jill A. Kanaley, Marcia L. Andresen-Reid, La Vonne Oenning, Bruce A. Kottke, Michael D. Jensen

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Upper-body obesity (UB Ob) is more strongly associated with adverse health consequences; however, few obesity-treatment studies have examined outcome according to body-fat distribution. To examine whether diet and formal- or informal-exercise instruction causes differential changes in health and lipid profiles, ten LB Ob and nine UB Ob premenopausal women received dietary intervention (2.1 MJ-deficit/d for 16 wk) and were randomly assigned to either formal- or informalexercise instruction. Weight loss was similar between groups (≈8 kg), and no change occurred in lean body mass or basal metabolic rate. Baseline cholesterol and triglycerides were greater (P < 0.01) in UB Ob than LB Ob women and decreased more (P < 0.01) in response to treatment in UB Ob women. Formal exercise instruction increased high-density-lipoprotein cholesterol (P < 0.05) especially in UB Ob women. Future studies on treatment of obesity should include consideration of regional fat distribution.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Issue number1
StatePublished - Jan 1993


  • Body composition
  • Caloric restriction
  • Exercise
  • Plasma lipids and lipoproteins

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)


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