Differential expression of human globin genes introduced in K562 cells.

D. Kioussis, F. Wilson, K. Khazaie, F. Grosveld

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We have constructed a series of hybrid globin genes between the 5' half of the human epsilon-, gamma- and beta-globin genes, and the 3' half of the rabbit beta-globin gene. These hybrid genes were introduced into the cell line K562. Analysis of the hybrid mRNA populations show that only the hybrid epsilon- and gamma-globin genes are expressed in these cells in concordance with the endogenous K562 globin gene expression. It is therefore likely that these cells contain transcriptional factors which allow the specific expression of introduced epsilon- and gamma-, but not beta-globin genes, irrespective of their chromosomal localization.

Original languageEnglish (US)
Pages (from-to)927-931
Number of pages5
JournalThe EMBO journal
Issue number4
StatePublished - Apr 1985

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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