Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease

for the Dominantly Inherited Alzheimer's Network

Research output: Contribution to journalArticlepeer-review


As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and “sporadic” late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences.

Original languageEnglish (US)
Pages (from-to)1754-1764
Number of pages11
JournalAlzheimer's and Dementia
Issue number10
StatePublished - Oct 2022


  • Alzheimer disease
  • autosomal dominant Alzheimer disease
  • cognitive
  • comorbidities
  • late-onset Alzheimer disease

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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