Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound

Ellen Farr; Alexis R. Wolfe; Swati Deshmukh; Leslie Rydberg; Rachna Soriano; James M. Walter; Andrea J. Boon; Lisa F. Wolfe; Colin K. Franz

doi:10.1002/acn3.51416

Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound

Ellen Farr, Alexis R. Wolfe, Swati Deshmukh, Leslie Rydberg, Rachna Soriano, James M. Walter, Andrea J. Boon, Lisa F. Wolfe, Colin K. Franz

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

Abstract

Many survivors from severe coronavirus disease 2019 (COVID-19) suffer from persistent dyspnea and fatigue long after resolution of the active infection. In a cohort of 21 consecutive severe post-COVID-19 survivors admitted to an inpatient rehabilitation hospital, 16 (76%) of them had at least one sonographic abnormality of diaphragm muscle structure or function. This corresponded to a significant reduction in diaphragm muscle contractility as represented by thickening ratio (muscle thickness at maximal inspiration/end-expiration) for the post-COVID-19 compared to non-COVID-19 cohorts. These findings may shed new light on neuromuscular respiratory dysfunction as a contributor to prolonged functional impairments after hospitalization for post-COVID-19.

Original language	English (US)
Pages (from-to)	1745-1749
Number of pages	5
Journal	Annals of Clinical and Translational Neurology
Volume	8
Issue number	8
DOIs	https://doi.org/10.1002/acn3.51416
State	Published - Aug 2021

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1002/acn3.51416

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title = "Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound",

abstract = "Many survivors from severe coronavirus disease 2019 (COVID-19) suffer from persistent dyspnea and fatigue long after resolution of the active infection. In a cohort of 21 consecutive severe post-COVID-19 survivors admitted to an inpatient rehabilitation hospital, 16 (76%) of them had at least one sonographic abnormality of diaphragm muscle structure or function. This corresponded to a significant reduction in diaphragm muscle contractility as represented by thickening ratio (muscle thickness at maximal inspiration/end-expiration) for the post-COVID-19 compared to non-COVID-19 cohorts. These findings may shed new light on neuromuscular respiratory dysfunction as a contributor to prolonged functional impairments after hospitalization for post-COVID-19.",

author = "Ellen Farr and Wolfe, {Alexis R.} and Swati Deshmukh and Leslie Rydberg and Rachna Soriano and Walter, {James M.} and Boon, {Andrea J.} and Wolfe, {Lisa F.} and Franz, {Colin K.}",

note = "Funding Information: No funding information provided. Publisher Copyright: {\textcopyright} 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association",

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T1 - Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound

AU - Farr, Ellen

AU - Wolfe, Alexis R.

AU - Deshmukh, Swati

AU - Rydberg, Leslie

AU - Soriano, Rachna

AU - Walter, James M.

AU - Boon, Andrea J.

AU - Wolfe, Lisa F.

AU - Franz, Colin K.

N1 - Funding Information: No funding information provided. Publisher Copyright: © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association

PY - 2021/8

Y1 - 2021/8

N2 - Many survivors from severe coronavirus disease 2019 (COVID-19) suffer from persistent dyspnea and fatigue long after resolution of the active infection. In a cohort of 21 consecutive severe post-COVID-19 survivors admitted to an inpatient rehabilitation hospital, 16 (76%) of them had at least one sonographic abnormality of diaphragm muscle structure or function. This corresponded to a significant reduction in diaphragm muscle contractility as represented by thickening ratio (muscle thickness at maximal inspiration/end-expiration) for the post-COVID-19 compared to non-COVID-19 cohorts. These findings may shed new light on neuromuscular respiratory dysfunction as a contributor to prolonged functional impairments after hospitalization for post-COVID-19.

AB - Many survivors from severe coronavirus disease 2019 (COVID-19) suffer from persistent dyspnea and fatigue long after resolution of the active infection. In a cohort of 21 consecutive severe post-COVID-19 survivors admitted to an inpatient rehabilitation hospital, 16 (76%) of them had at least one sonographic abnormality of diaphragm muscle structure or function. This corresponded to a significant reduction in diaphragm muscle contractility as represented by thickening ratio (muscle thickness at maximal inspiration/end-expiration) for the post-COVID-19 compared to non-COVID-19 cohorts. These findings may shed new light on neuromuscular respiratory dysfunction as a contributor to prolonged functional impairments after hospitalization for post-COVID-19.

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IS - 8

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Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound

Abstract

ASJC Scopus subject areas

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