Diagnostic and therapeutic implications of type 2 myocardial infarction: Review and commentary

Joseph S. Alpert, Kristian A. Thygesen, Harvey D. White, Allan S. Jaffe

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


The Task Force for the Universal Definition of Myocardial Infarction recently published updated guidelines for the clinical and research diagnosis of myocardial infarction under a variety of circumstances and in a variety of categories. A type 1 myocardial infarction (MI) is usually the result of atherosclerotic coronary artery disease with thrombotic coronary arterial obstruction secondary to atherosclerotic plaque rupture, ulceration, fissuring, or dissection, causing coronary arterial obstruction with resultant myocardial ischemia and necrosis. Patients with a type 2 MI do not have atherosclerotic plaque rupture. In this latter group of patients, myocardial necrosis occurs because of an increase in myocardial oxygen demand or a decrease in myocardial blood flow. Type 2 MI has been the subject of considerable clinical discussion and confusion. This review by knowledgeable members of the Task Force seeks to help clinicians resolve the confusion surrounding type 2 MI.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalAmerican Journal of Medicine
Issue number2
StatePublished - Feb 2014


  • Clinical definition
  • Myocardial infarction
  • Troponin

ASJC Scopus subject areas

  • General Medicine


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