Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Morie A. Gertz, Merrill D. Benson, Peter J. Dyck, Martha Grogan, Terresa Coelho, Marcia Cruz, John L. Berk, Violaine Plante-Bordeneuve, Hartmut H.J. Schmidt, Giampaolo Merlini

Research output: Contribution to journalReview articlepeer-review

197 Scopus citations


Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

Original languageEnglish (US)
Pages (from-to)2451-2466
Number of pages16
JournalJournal of the American College of Cardiology
Issue number21
StatePublished - 2015


  • familial amyloid cardiomyopathy
  • familial amyloid polyneuropathy
  • genetics
  • liver transplantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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