Diabetic neuropathies: Classification, clinical features, and pathophysiological basis

Michael Sinnreich, Bruce V. Taylor, P. James B. Dyck

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


Diabetes mellitus is associated with a wide spectrum of neuropathy syndromes, ranging from a mild asymptomatic distal sensory neuropathy to a severe disabling radiculoplexus neuropathy. As the pathophysiology of these separate conditions is better understood, classification of the various phenotypes becomes important because of treatment implications. Here we provide a short summary of the history of the classification of diabetic neuropathies and try to describe the most common forms classified according to their presumed pathophysiology. We have tried to include epidemiological data where available, as well as histopathology of nerve in several diabetic neuropathies.

Original languageEnglish (US)
Pages (from-to)63-79
Number of pages17
Issue number2
StatePublished - Mar 2005


  • Diabetes mellitus
  • Diabetic lumbosacral radiculoplexus neuropathy
  • Diabetic neuropathy
  • Diabetic polyneuropathy

ASJC Scopus subject areas

  • Clinical Neurology


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