Dexmedetomidine and mannitol for awake craniotomy in a pregnant patient

Kathryn S. Handlogten, Emily E. Sharpe, Brian C. Brost, Ian F. Parney, Jeffrey J. Pasternak

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We describe the use of dexmedetomidine for an awake neurosurgical procedure in a pregnant patient and quantify the effect of mannitol on intrauterine volume. A 27-year-old woman underwent a craniotomy, with intraprocedural motor and speech mapping, at 20 weeks of gestation. Sedation was maintained with dexmedetomidine. Mannitol at 0.25 g/kg IV was administered to control brain volume during surgery. Internal uterine volume was estimated at 1092 cm3 before surgery and decreased to 770 and 953 cm3 at 9 and 48 hours, respectively, after baseline assessment. No adverse maternal or fetal effects were noted during the intraoperative period or up to 48 hours postoperatively.

Original languageEnglish (US)
Pages (from-to)1099-1103
Number of pages5
JournalAnesthesia and analgesia
Issue number5
StatePublished - May 25 2015

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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