Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection

Raymund R. Razonable, Antonio Rivero, Robert A. Brown, Gregory D. Hart, Mark J. Espy, Hester van Cruijsen, Jennie Wilson, Cynthia Groettum, Walter Kremers, Thomas F. Smith, Carlos V. Paya

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Human herpesvirus (HHV)-6 and HHV-7 are increasingly being recognized as emerging pathogens among transplant recipients. Using quantitative polymerase chain reaction assays, we demonstrate the presence of HHV-6 and/or HHV-7 in 18 of 20 episodes of clinically presumed or microbiologically confirmed cytomegalovirus (CMV) infection. Seventeen (89%) of 19 microbiologically confirmed cytomegalovirus (CMV)-infected patients had concomitant HHV-6 variant B (47%) and/or HHV-7 (63%) infection. The degree of HHV-6 coinfection was significantly correlated with hyperbilirubinemia while HHV-7 coinfection demonstrated a non-significant trend toward cytopenias. In one of the 20 episodes described herein, the 'viral syndrome' was due solely to HHV-7 infection; clinical and virological response was observed during intravenous ganciclovir therapy in this patient. While this study emphasizes the significance of HHV-6 and/or HHV-7 coinfection during episodes of CMV infection, it significantly highlights the novel observation of the causal role of HHV-7 (in the absence of HHV-6 and CMV) in a clinical illness presumed to be caused CMV. Thus, HHV-7 (and HHV-6) should be considered as a pathogen (or copathogen) in the viral syndromes following organ transplantation.

Original languageEnglish (US)
Pages (from-to)114-120
Number of pages7
JournalClinical Transplantation
Issue number2
StatePublished - Apr 2003


  • Cytomegalovirus
  • Human herpesvirus-6
  • Human herpesvirus-7
  • Transplantation

ASJC Scopus subject areas

  • Transplantation


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