Designer natriuretic peptides

Candace Y W Lee; Hsiao Lieu; John C Jr. Burnett

doi:10.231/JIM.0b013e3181946fb2

Designer natriuretic peptides

Candace Y W Lee
, Hsiao Lieu
, John C Jr. Burnett

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed.

Original language	English (US)
Pages (from-to)	18-21
Number of pages	4
Journal	Journal of Investigative Medicine
Volume	57
Issue number	1
DOIs	https://doi.org/10.231/JIM.0b013e3181946fb2
State	Published - Jan 2009

Keywords

Hybrid peptides
Natriuretic peptide
Renal function

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

Access to Document

10.231/JIM.0b013e3181946fb2

Cite this

@article{aeb465eacdb34df2a2a433df06609dc2,

title = "Designer natriuretic peptides",

abstract = "Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed.",

keywords = "Hybrid peptides, Natriuretic peptide, Renal function",

author = "Lee, \{Candace Y W\} and Hsiao Lieu and Burnett, \{John C Jr.\}",

year = "2009",

month = jan,

doi = "10.231/JIM.0b013e3181946fb2",

language = "English (US)",

volume = "57",

pages = "18--21",

journal = "Journal of Investigative Medicine",

issn = "1081-5589",

publisher = "SAGE Publications Inc.",

number = "1",

}

TY - JOUR

T1 - Designer natriuretic peptides

AU - Lee, Candace Y W

AU - Lieu, Hsiao

AU - Burnett, John C Jr.

PY - 2009/1

Y1 - 2009/1

N2 - Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed.

AB - Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed.

KW - Hybrid peptides

KW - Natriuretic peptide

KW - Renal function

UR - https://www.scopus.com/pages/publications/63249103314

UR - http://www.scopus.com/inward/citedby.url?scp=63249103314&partnerID=8YFLogxK

U2 - 10.231/JIM.0b013e3181946fb2

DO - 10.231/JIM.0b013e3181946fb2

M3 - Article

C2 - 19158603

SN - 1081-5589

VL - 57

SP - 18

EP - 21

JO - Journal of Investigative Medicine

JF - Journal of Investigative Medicine

IS - 1

ER -

Designer natriuretic peptides

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this