Depression before and after diagnosis of multiple sclerosis.

M. J. Sullivan, B. Weinshenker, S. Mikail, K. Edgley

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Depression was examined in 45 patients evaluated within 2 months of diagnosis of MS. At the time of testing, 40% of the MS sample met the diagnostic criteria for major depression, 22% had adjustment disorder with depressed mood and 37% showed no evidence of mood disorder. Personal and family history of depression in patients with MS was also examined and compared with a sample of patients with chronic low back pain (CLBP) who were matched for age, gender, marital and employment status and current level of depression. Fifty-two per cent of patients with MS reported experiencing a depressive episode before the onset of MS compared with 17% of patients with CLBP (P < 0.001). Sixteen patients with MS (35%) reported family history (parent or sibling) of treatment for depression compared with seven (15%) of patients with CLBP (P < 0.05). MS patients with a history of depression reported more initial symptoms than MS patients without a history of depression. Clinical and theoretical implications of the findings are discussed.

Original languageEnglish (US)
Pages (from-to)104-108
Number of pages5
JournalMultiple sclerosis (Houndmills, Basingstoke, England)
Issue number2
StatePublished - Jun 1995

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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