Dementia without alzheimer pathology

Charles W. Heilig, David S. Knopman, Angeline R. Mastri, William Frey

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


We studied five demented patients who, on neu- ropathologic examination, had cell loss and Lewy bodies in substantia nigra and locus ceruleus and few Alzheimer-type changes. The nucleus basalis had minimal cell loss in three patients and was not available in two. The lesions in the substantia nigra and locus ceruleus were unlikely to account for the dementia, and other structural or biochemical derangements, probably cortical but possibly subcortical, must also have been present but not visible at the light microscopic level.

Original languageEnglish (US)
Pages (from-to)762-765
Number of pages4
Issue number5
StatePublished - May 1985

ASJC Scopus subject areas

  • Clinical Neurology


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