Definitions, epidemiology and prognostication of liver disease

Jody C. Olson, Patrick S. Kamath

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Patients presenting to the intensive care unit with liver failure may be categorized into two main subtypes, those with acute liver failure and those with complications of chronic liver diseases, the former being a rare condition and the latter far more common. In both categories, patients presenting with liver failure have phenotypical features of multi-system failure, a deranged inflammatory response, and pose unique challenges for management in the intensive care unit. Differentiating acute liver failure from the liver failure associated with chronic liver disease is of critical diagnostic importance, as management strategies are distinctly different. The purpose of this chapter is to review the definitions of liver failure, the epidemiology of liver disease, and current tools to aid in prognosis of liver failure.

Original languageEnglish (US)
Title of host publicationHepatic Critical Care
PublisherSpringer International Publishing
Number of pages8
ISBN (Electronic)9783319664323
ISBN (Print)9783319664316
StatePublished - Jan 8 2018


  • Acute liver failure
  • Acute-on-chronic liver failure
  • Cirrhosis
  • MELD

ASJC Scopus subject areas

  • General Medicine


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