D-Penicillamine in Felty's syndrome

S. Lakhanpal, H. S. Luthra

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We report our experience with 8 patients with Felty's syndrome who were treated with D-penicillamine for a mean of one year. Six of the 8 patients experienced improvement in their neutropenia. Cutaneous ulcers healed in 4 of 6, while recurrent infections cleared in 3 of 5 patients. The drug was withdrawn in 6 patients - lack of response in one, thrombocytopenia in one, urticaria in one, rash in one, and granulocytopenia in 2. One of the latter 2 patients developed pancytopenia and died. Although D-penicillamine is effective in treatment of Felty's syndrome, its side effects can be serious and potentially lethal. Its use should be limited to patients who have failed other treatments.

Original languageEnglish (US)
Pages (from-to)703-706
Number of pages4
JournalJournal of Rheumatology
Issue number4
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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