Cytotoxic constituents of Achillea clavennae from Montenegro

Snežana Trifunović, Vlatka Vajs, Zorica Juranić, Željko Žižak, Vele Tešević, Slobodan Macura, Slobodan Milosavljević

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9-11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9α-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.

Original languageEnglish (US)
Pages (from-to)887-893
Number of pages7
Issue number9
StatePublished - May 2006


  • Achillea clavennae
  • Asteraceae
  • Bisabolenes
  • Cytotoxicity
  • Flavonoids
  • Guaianolides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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