Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients

Gunnar Juliusson; David Oscier; G. Juliusson; G. Gahrton; D. Oscier; M. Fitchett; F. Ross; V. Brito-Babapulle; D. Catovsky; S. Knuutila; E. Elonen; M. Lechleitner; J. Tanzer; M. Schoenwald; G. L. Castoldi; A. Cuneo; P. Nowell; L. Peterson; N. Kay

doi:10.3109/10428199109103374

Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients

Gunnar Juliusson, David Oscier, G. Juliusson, G. Gahrton, D. Oscier, M. Fitchett, F. Ross, V. Brito-Babapulle, D. Catovsky, S. Knuutila, E. Elonen, M. Lechleitner, J. Tanzer, M. Schoenwald, G. L. Castoldi, A. Cuneo, P. Nowell, L. Peterson, N. Kay

Hematology

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Chromosome analysis on CLL-cells from 649 patients revealed clonal changes in 311 cases (48% The most common abnormalities were trisomy 12 (n = 112), and structural changes on the long arm of chromosome 13 (n = 62), most of them interstitial deletions or translocations involving 13q14, the site of the retinoblastoma gene. Complex karyotypes were associated with poor prognosis, although karyotypic changes rarely develop during the course of the disease. Among patients with single chromosomal abnormalities those with trisomy 12 had a poor survival, whereas those with structural changes on chromosome 13 had as good a prognosis as patients with a normal karyotype.

Original language	English (US)
Pages (from-to)	21-25
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	5
Issue number	S1
DOIs	https://doi.org/10.3109/10428199109103374
State	Published - 1991

Keywords

CLL
Cytogenetic findings
Survival

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.3109/10428199109103374

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Juliusson, G., Oscier, D., Juliusson, G., Gahrton, G., Oscier, D., Fitchett, M., Ross, F., Brito-Babapulle, V., Catovsky, D., Knuutila, S., Elonen, E., Lechleitner, M., Tanzer, J., Schoenwald, M., Castoldi, G. L., Cuneo, A., Nowell, P., Peterson, L., & Kay, N. (1991). Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients. Leukemia and Lymphoma, 5(S1), 21-25. https://doi.org/10.3109/10428199109103374

Juliusson, G, Oscier, D, Juliusson, G, Gahrton, G, Oscier, D, Fitchett, M, Ross, F, Brito-Babapulle, V, Catovsky, D, Knuutila, S, Elonen, E, Lechleitner, M, Tanzer, J, Schoenwald, M, Castoldi, GL, Cuneo, A, Nowell, P, Peterson, L & Kay, N 1991, 'Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients', Leukemia and Lymphoma, vol. 5, no. S1, pp. 21-25. https://doi.org/10.3109/10428199109103374

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title = "Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients",

abstract = "Chromosome analysis on CLL-cells from 649 patients revealed clonal changes in 311 cases (48% The most common abnormalities were trisomy 12 (n = 112), and structural changes on the long arm of chromosome 13 (n = 62), most of them interstitial deletions or translocations involving 13q14, the site of the retinoblastoma gene. Complex karyotypes were associated with poor prognosis, although karyotypic changes rarely develop during the course of the disease. Among patients with single chromosomal abnormalities those with trisomy 12 had a poor survival, whereas those with structural changes on chromosome 13 had as good a prognosis as patients with a normal karyotype.",

keywords = "CLL, Cytogenetic findings, Survival",

author = "Gunnar Juliusson and David Oscier and G. Juliusson and G. Gahrton and D. Oscier and M. Fitchett and F. Ross and V. Brito-Babapulle and D. Catovsky and S. Knuutila and E. Elonen and M. Lechleitner and J. Tanzer and M. Schoenwald and Castoldi, {G. L.} and A. Cuneo and P. Nowell and L. Peterson and N. Kay",

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T1 - Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients

AU - Juliusson, Gunnar

AU - Oscier, David

AU - Juliusson, G.

AU - Gahrton, G.

AU - Oscier, D.

AU - Fitchett, M.

AU - Ross, F.

AU - Brito-Babapulle, V.

AU - Catovsky, D.

AU - Knuutila, S.

AU - Elonen, E.

AU - Lechleitner, M.

AU - Tanzer, J.

AU - Schoenwald, M.

AU - Castoldi, G. L.

AU - Cuneo, A.

AU - Nowell, P.

AU - Peterson, L.

AU - Kay, N.

PY - 1991

Y1 - 1991

N2 - Chromosome analysis on CLL-cells from 649 patients revealed clonal changes in 311 cases (48% The most common abnormalities were trisomy 12 (n = 112), and structural changes on the long arm of chromosome 13 (n = 62), most of them interstitial deletions or translocations involving 13q14, the site of the retinoblastoma gene. Complex karyotypes were associated with poor prognosis, although karyotypic changes rarely develop during the course of the disease. Among patients with single chromosomal abnormalities those with trisomy 12 had a poor survival, whereas those with structural changes on chromosome 13 had as good a prognosis as patients with a normal karyotype.

AB - Chromosome analysis on CLL-cells from 649 patients revealed clonal changes in 311 cases (48% The most common abnormalities were trisomy 12 (n = 112), and structural changes on the long arm of chromosome 13 (n = 62), most of them interstitial deletions or translocations involving 13q14, the site of the retinoblastoma gene. Complex karyotypes were associated with poor prognosis, although karyotypic changes rarely develop during the course of the disease. Among patients with single chromosomal abnormalities those with trisomy 12 had a poor survival, whereas those with structural changes on chromosome 13 had as good a prognosis as patients with a normal karyotype.

KW - CLL

KW - Cytogenetic findings

KW - Survival

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Cytogenetic findings and survival in b-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients

Abstract

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